A comparison of time-related changes in trans-nonachlor, oxychlordane and trans-chlordane residues in rat tissues and the relationship between tissue residue levels, functional changes and gender.

Updated 2015-10-05

Short term: To compare changes in trans-nonachlor, oxychlordane and trans-chlordane residues over time in fat and other tissues (using the rat model), and to relate fat and tissue residue levels to clinical changes in male and female rats. Long term: To provide current information on the toxicity of chlordane metabolites and constituents, including trans-nonachlor and oxychlordane.

This is not a National Implementation Plan (NIP) project

Status: Planned
Project time span: 2000 - 2002
Data collection: 2000 - 2001
Data processing: 2001 - 2002
Data reporting: 2002 - 2002

Contact information

Contact person: Genevieve S. Bondy
Address: Regulatory Toxicology Research Division Postal Locator 2202D Food Directorate Health Protection Branch Health Canada 2E Banting Building Ottawa, Ontario Canada K1A 0L2
Phone: +1 613 957 2051
Fax: +1 613 941 6959
Email: ac.cg.cs-ch@ydnoB_eveiveneG

Parameters and Media

Parameter groups measured/observed/modelled

Biological effects

Persistent organic pollutants (POPs)

Media sampled/studied/modelled

Additional information or further specification of types of data / information collected, species / tissues / organs sampled, etc.

Animal model: Sprague-Dawley rat Tissues sampled/endpoints measured: Residue levels (trans-nonachlor, oxychlordane and trans-chlordane) in adipose, liver and kidneys; clinical changes indicative of liver and kidney function; molecular changes indicative of microsomal enzyme induction and cellular proliferation; biomarkers of cellular proliferation in multiple tissues, including mammary glands, liver and kidneys; total body fat levels in male and female rats.

Geography

Regions studied: None specified
Other areas: Toxicological studies applicable to any region where chlordane-related contaminants are present in the food chain

Data availability

Are data archived or planned to be archived at an AMAP Thematic Data Centre?: no
If no (or only part of data are reported to a TDC), where and how are (other) data stored?: Data published in peer-reviewed journals
References to key publications (or planned publications) and data reports: Bondy, G., Coady, L., Doucet, J., Moisey, J., Armstrong, C., Robertson, P., Kriz, R., Liston, V. and Norstrom, R. 2005. Enantioselective and gender-dependent depletion of chlordane compounds from rat tissues. J. Toxicol. Environ. Health 68: 1917-1938.

Samples/specimens archived in specimen banks?: No

Methods & Procedures

Not specified

Additional Information

Is this a bi- AND multi-lateral project (i.e. a project involving cooperation between different countries)?: No
Other institutes involved in the project: Environment Canada
Is this project reporting to other organizations/programmes?: Northern Contaminants Program Indian and Northern Affairs Canada